发给老马备查:
5 q8 E* M$ O" |- _, [4 ~滴水察海(69304838) 15:23:23
0 i4 g1 ]' b+ k9 G8 d. H& }老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱- u& i+ J( V Q1 h
吉非替尼和S-1连用的依据1 K% d, M6 s: X
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
6 ~6 H) N- \3 Z0 \6 M2 D2 _是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达, `6 U0 ]' Y% D6 e! G
这样是不是推理出,耐药后,可以用S-1和培美了?
) U+ e2 R2 L/ Q% O, f结论:, i* t1 O6 K5 K: \2 l- C
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |